It can then be assumed that although systemic GH may lack a direct effect on the induction and/or progression of these tumors, some growth factors induced by GH, like IGF-1, EGF and VEGF, could negatively affect tumor growth through NHE stimulation and/or cellular alkaline pH changes, an effect that was first described from seminal publications decades ago (Figure 1) [67,68,69]. The gene discussed is IGF1; the disease is neoplasm.