To our knowledge, the rate of TNF-α inhibitor-induced neutropenia has been comparable to that of neutropenia associated with commonly prescribed disease-modifying anti-rheumatic drugs (DMARD), such as methotrexate and leflunomide, with a neutropenia rate between 10 and 15% [16,19,20,21,22,23,24]. Here, TNF is linked to Decreased total neutrophil count.