TNF and Sepsis: However, our results showed that TSLP neutralization allowed significant decreases in production of TNF-α in RAW 264.7 cells; TSLP-deficient mice had significantly less TNF-α levels in liver; nutlin-3a significantly suppressed production of TNF-α and an increase of proinflammatory response by TSLP action in an LPS-induced sepsis model.