PPARG and Chronic colitis: In agreement with the literature, experimental murine models of intestinal inflammation have confirmed the protective effects of dietary EVOO supplementation on DSS-induced chronic colitis through peroxisome proliferator-activated receptor gamma (PPAR-γ) up-regulation and mitogen activated protein kinases (MAPKs)/nuclear transcription factor-kappa B (NF-κB) signaling pathways inhibition, decreasing the inflammatory cascade [153].