LncRNA DLEU1 and DLEU2 are located in the region of chromosome 13q14.3 [332,333], and they are reported to be involved in the pathogenesis of several types of solid tumors such as HCC [334], CRC [335], LSCC [336], PC [337], OC [338], etc. Nava-Rodríguez et al. reported that a CLL patient has genomic instability and a 13q14 deletion involving the DLEU1, DLEU2, and RB1 genes. The gene discussed is DLEU2; the disease is B-cell chronic lymphocytic leukemia.