However, TUG1 knockdown significantly inhibits cell proliferation, migration, and invasion and promotes cell apoptosis and cell cycle arrest in three SCLC cell lines (NCI-H69, NCI-H446, NCIH69AR) by regulating LIMK2b (a splice variant of LIM-kinase 2) expression via binding with enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) [85]. This evidence concerns the gene TUG1 and small cell lung carcinoma.