CASC15 and neuroblastoma: Researches have demonstrated that knockdown of CASC15 and NBAT1 in NB cell line can prevent neuronal differentiation through increasing nucleolar localization of ubiquitin specific peptidase 36 (USP36), activating SOX9 by regulating chromodomain helicase DNA binding protein 7 (CHD7) ubiquitination [379], and upregulating RE1 silencing transcription factor (REST/NRSF) [381].