In a longer time-frame (i.e., 0–2 × 105 s), while in the non-mutated tumor, the concentration of PD-L1 reached its plateau concentration at t = 1.3 × 105 s, in the ALKF1174L mutated tumor the concentration of PD-L1 continued to increase in a linear fashion (Figure 4A). This evidence concerns the gene CD274 and neoplasm.