The lower positive rates of IGF-1 in the BF + LYC-treated (up to 50%) and Metformin-treated groups (by 67%) might be of major relevance in our study, since in a previous study, the incidence of tumor growth on the caecum was significantly lower in liver-specific IGF-1-deficient mice orthotopically transplanted with colon 38 adenocarcinoma tissue fragments [32], in which serum IGF-1 levels were 25% of those in control mice. This evidence concerns the gene IGF1 and neoplasm.