Since the IGF-1/IFG-1R system plays a critical role in the development, proliferation, invasion, and survival of colorectal cancer cells [20], we proceeded to demonstrate the synergistic effect of the combined probiotic BF + LYC supplementation on the expression of several IGF system components as an effective strategy for colon cancer chemoprevention. The gene discussed is IGF1; the disease is colorectal cancer.