As shown in the lower panel of Figure 3, the positive rates of IGF-1, IGF-2 and IGF-1R expression in colonic samples of the Normal group were 60%, 50%, and 33% lower, respectively, as compared to those of colonic samples of the AOM + DSS control group (Chi-square test, p < 0.05). Here, IGF2 is linked to infectious otitis media.