IGFBP3 and adenocarcinoma: In our study, we could suggest that the DSS-induced inflammation does not favor the evolution to adenocarcinomas in BF- and Metformin-treated groups and the modulation of the expression of IGF-1/IGF-1R/IGFBP3 protein might be involved in the suppressive mechanisms underlying the evolution to adenocarcinomas in the AOM + DSS model of colon carcinogenesis.