However, having mentioned that the underlying pathophysiological links with the IGF-1/IGF-1R/IGFPs system are still barely understood and the molecular mechanisms still remain unsolved [4], the BF + LYC 20 supplementation showed strongly decreased expressions of IGF-1, IGFBP2, and IGF-1R; while the IGFBP3 protein expression increased in the colon after AOM + DSS treatment (Figure 4), which has not been previously reported with a new form of as BF microencapsulated using the spray drying technique. This evidence concerns the gene IGFBP2 and infectious otitis media.