Similar to the higher IGF-2 and IGFBP2 expressions in the AOM + DSS control group, mean IGFBP2 SD scores and expressions were significantly higher in sera and tumors from patients with colonic neoplasia compared to healthy individuals, whereas mean IGF-2 SDs were elevated in Dukes A and Dukes B cases compared with controls, but not in advanced disease [34,35]. Here, IGFBP2 is linked to infectious otitis media.