LCN2 and obesity due to melanocortin 4 receptor deficiency: The results of this study demonstrated that long-term HFD-induced obesity combined with prediabetic metabolism was accompanied by collagen type IV accumulation in renal glomeruli and enhanced tubular Lcn2 (NGAL) production in Long-Evans rats, but otherwise renal function and morphology were preserved, while injury was observed in the heart and liver in the same animals.