Lipophilic antipsychotic drugs, known to cross the BBB effectively to bind to central dopamine D2 receptors and promote their therapeutic action, are able to modulate many cancer-associated intracellular signaling pathways, such as PI3K-AKT-mTOR, STAT3, and WNT [188], and may act as anti-cancer drugs. The gene discussed is STAT3; the disease is cancer.