BLMH and vulva cancer: For example, Bleomycin, which can be used for cervical, head and neck, lymphomas, penile, testicular, and vulvar cancer [25], showed bleomycin hydrolase [26,27,28] as a mechanism of detoxification, and the increased activity of bleomycin hydrolase, N-acetylating enzymes, and bleomycin-binding proteins [27,28,29], as mechanisms of resistance (Supplementary Table S1).