Other checkpoints can also be implicated in tumor immune escape such as Lymphocyte activation gene 3 protein (LAG-3) and T-cell immunoglobulin and mucin domain-containing 3 (TIM-3), IDO1, B- and T-lymphocyte attenuator (BTLA), V-domain immunoglobulin suppressor of T-cell activation (VISTA) and the A2A adenosine receptor (A2A-R) [170,171]. This evidence concerns the gene ADORA2A and neoplasm.