STAT3 and neoplasm: Moreover, many inhibitors were proposed such as the XIAP inhibitor embelin [139], PM01183 a novel synthetic agent derived from trabectedin [140], alisertib (MLN8237), a small-molecule inhibitor of Auror-A kinase [141], STATTIC or BBI608 [142] to inhibit STAT3 in MDSCs with a potential clinical application to favor anti-tumor response.