M2 macrophages participate in tumor growth by releasing proangiogenic cytokines and growth factors, e.g. Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Colony Stimulating Factor-1 (CSF-1), and basic Fibroblast Growth Factor (βFGF). This evidence concerns the gene EGF and neoplasm.