STAT3-depleted DCs with adenoviral STAT3 short hairpin RNA (shRNA) or siRNA presented an altered cytokines production profile under TLR stimulation (such as more IL-12 and TNF-α and less IL-10), and induced tumor Ag-specific T-cells and IFN-γ-producing γδ T lymphocytes more efficiently than control DCs [119,120,121]. This evidence concerns the gene TNF and neoplasm.