Since no primary tumor material was available, an innovative procedure was used to prepare the IO-VACR vaccine: After 5 days of pre-treatment with mEHT plus NDV infusion, the EDIM/PanTum Detect assay revealed a significant increase in the blood of monocytes that had phagocytosed tumor material, as revealed by Apo10 and TKTL1 positivity. Here, TKTL1 is linked to neoplasm.