CD28 and neoplasm: ATV-NDV tumor vaccine with attached anti-HN-anti-CD3 (αHN-αCD3) and anti-HN-anti-CD28 (αHN-αCD28) bsAb exerted in vitro, upon stimulation of allogeneic human peripheral blood mononuclear cells (PBMC), strong and durable antitumor effects against human tumor cell monolayers [152].