Recently, evidence has been collected upon the comparison of irRECIST and the newly-defined iRECIST in a retrospective dataset of NSCLC patients treated with anti-PD1 or anti-PD-L1 ICIs, showing a 3.8% discrepancy rate between the two criteria, accounting for discordances with a potential impact on the therapeutic decision-making [28]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.