FGF1 and neoplasm: The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) system can be altered in a portion of UCs, and various FGFs (including FGF1 and FGF2) are found in urines and tumor tissues of bladder cancer patients and are frequently expressed (FGF1/2/5 and 8) in human bladder carcinoma cell lines [3,4].