CASP3 and Zika virus infectious disease: Likewise, phloretin reduces ZIKV infection by decreasing apoptotic caspase-3 and -7 activities and by reducing AKT/mTOR phosphorylation pathways, which, together with the fact that 2-deoxy-D-glucose disruption of cellular glucose availability inhibits ZIKV propagation, remarks the importance of glucose pathways for ZIKV propagation [183].