To assess the possibility to use VNB photoporation for efficient macromolecular delivery into mammalian tumor cells (B16 cells), we first applied fluorescently labeled dextrans (FITC-dextran) of 70 kDa (FD70), which are only slightly larger than the proteins of interest (murine MLKL: 56.3 kDa, active murine caspase-3: 32 kDa and active murine caspase-8: 55 kDa). This evidence concerns the gene CASP8 and neoplasm.