Six IA genes, APOB, IMPDH1, SEC61G, IQGAP2, TAGAP, and IGKV4-1, were dysregulated (differential expression, p < 0.05) in only tumor samples of drinkers without hepatitis B virus (HBV) infection as compared to pure normal samples (from nondrinkers). Here, IGKV4-1 is linked to neoplasm.