In conclusion, the ethanolic extract from the seeds of Annona cherimola Mill., a traditionally used plant seed with toxic properties, has been shown to exhibit a promising cytotoxic effect on AML cell lines, by inducing apoptosis through a p53-dependent mechanism and through the induction of both the intrinsic and extrinsic apoptotic pathways and decreasing the ROS levels. The gene discussed is TP53; the disease is acute myeloid leukemia.