Activation of Wnt pathway by non-canonical ligands, such as GATA6 [25], R-spondin [26], R-spondin2 [27], cullin 4B (CUL4B) [28], CDK8, K-ras [29], Rab5a and Rab11a [30,31], and MUC1 and MCU4 [32,33], leads to a progression of pancreatic cancer. Here, CUL4B is linked to familial pancreatic carcinoma.