Specifically TS positivity (reflects 5‐fluoruracil resistance22) was associated with MSI‐H status in all nine tumor types (colorectal [p < 0.001], cholangiocarcinoma [p = 0.022], epithelial ovarian cancer [p = 0.031], female genital tract malignancy [p < 0.0001], gastric cancer [p < 0.001], neuroendocrine tumor [p = 0.025], cancer with unknown primary [p < 0.001], pancreatic [p < 0.001] and small intestinal cancers [p = 0.003]). Here, TYMS is linked to cancer.