TUBB3 positivity, a marker for taxane resistance,26, 27, 28 was associated with PD‐L1 expression in soft tissue sarcoma (p = 0.027), cancer with unknown primary tumors (p = 0.019), nonsmall cell lung cancer (p < 0.001), kidney cancer (p = 0.006), head and neck cancer (p = 0.035), gastric cancer (p = 0.001), esophageal cancer (p = 0.004) and bladder cancer (p = 0.001). Here, TUBB3 is linked to head and neck cancer.