TS positivity (negativity is associate with improved responses to 5‐flurouracil, pemetrexed and capecitabine23, 24, 25) was associated with TMB‐H status in nine tumor types: small intestinal cancer (p = 0.001), pancreatic cancer (p = 0.002), cancer with unknown primary tumors (p = 0.001), nonsmall cell lung cancer (p < 0.001), gastric cancer (p < 0.001), female genital tract malignancy (p < 0.001), epithelial ovarian cancer (p = 0.031), cholangiocarcinoma (p = 0.029) and colorectal cancer (p < 0.001). The gene discussed is TYMS; the disease is cholangiocarcinoma.