NLRP3 and infection: We injected MAYV at 105 or 106 PFU dose in the footpad of WT and Nlrp3-/- mice and observed that Nlrp3–/–mice had increased footpad swelling compared to WT mice at 5 days post infection with a dose of 105 PFU and at 6 days post infection with a dose of 106 PFU (Fig 5A, 5B and 5C).