The prednisone was the most used medicine to treat leprosy reactions, especially type 1 reactions, as expected, given that corticosteroids are recognized as the drug of choice in this reaction for its suppressive effect on the inflammatory process, diminishing the INF-ɣ and TNF-α pro-inflammatory cytokines, and for their importance in the recovery of neural functions in the post-reactional period [27]. This evidence concerns the gene CBLIF and leprosy.