In order to examine the role of p75NTR in Tau hyperphosphorylation, we crossed pR5 Tauopathy mice carrying the human Tau P301L mutation with p75KO mice which have a deletion of exon III of p75NTR to obtain pR5p75-/- (pR75KO) (Figure 1A). This evidence concerns the gene NGFR and tauopathy.