The neurotrophin receptor p75NTR has been found to mediate critical pathological conditions in AD, such as (1) neurite degeneration [55, 66], (2) neuronal death via Aβ [54, 67, 68] and via proNGF [55, 69, 70], and (3) increased Aβ production [71, 72]. Here, NGFR is linked to Alzheimer disease.