Our results can be explained by the fact that cancer is a long-term result of HP infection and it starts to disappear as hypochlorhydria sets in.35-37Prevalence of HP vacA s1+m1+ strains was 33.3%.This rate is similar to that reported in southern Mexico (38.5%)38 but lower than frequencies found in other regions of Mexico, Colombia, and Brazil.31,32,34 This strain has been described as more aggressive; however, we did not find higher rates in GC samples compared with CG samples. Here, HP is linked to cancer.