Mutations in CLCN2, which codes for ClC‐2, are responsible for leukoencephalopathy with ataxia (LKPAT) (Depienne et al., 2013) and ClC‐2 has been related to megalencephalic leukoencephalopathy with subcortical cysts (MLC) (Hoegg‐Beiler et al., 2014; Jeworutzki et al., 2012; Sirisi et al., 2017). This evidence concerns the gene CLCN2 and Ataxia.