Mutations in CLCN2, which codes for ClC‐2, are responsible for leukoencephalopathy with ataxia (LKPAT) (Depienne et al., 2013) and ClC‐2 has been related to megalencephalic leukoencephalopathy with subcortical cysts (MLC) (Hoegg‐Beiler et al., 2014; Jeworutzki et al., 2012; Sirisi et al., 2017). The gene discussed is CLCN2; the disease is Leukoencephalopathy.