CLCN2 and primary aldosteronism: In fact, the opening of voltage dependent Ca2+ channels has been proposed as the mechanism behind the increase in aldosterone production and secretion (Fernandes‐Rosa et al., 2018) resulting from gain‐of‐function mutations of CLCN2, which are behind primary aldosteronism and cause sustained depolarization of glomerulosa adrenal cells (Fernandes‐Rosa et al., 2018; Scholl et al., 2018).