Following orthotopic injection of control (Ctrl) KrasG12D HCC cells or sgRNA-24 KrasG12D HCC cells into the subcapsular region of the median liver lobe of wild-type mice, we monitored survival over a period of 4 weeks and found that Snora24 reduction, decreased the overall survival of mice compared to controls (p=0.017) (Figure 2E, left panel n = 4 mice per arm). This evidence concerns the gene SNORA24 and hepatocellular carcinoma.