Interestingly, two H/ACA snoRNAs, SNORA24 and SNORA67, identified in our expression analysis upon RASG12V-induced senescence (Figure 1A and Figure 1—figure supplement 1B), were significantly decreased in HCC specimens compared to matched adjacent non-tumor tissue (p<1.35×10−9 and p<4.6×10−7, respectively). Here, SNORA67 is linked to neoplasm.