IFNL4 and liver disorder: These associations between polymorphisms on the HCV polyprotein and host IFNL4 SNP rs12979860 genotypes are further intriguing given that variants within the IFNL4 locus (including SNP rs12979860) contribute to HCV clinical and biological outcomes, including spontaneous virus clearance, response to IFN-based treatment, viral load and liver disease progression (Aoki et al., 2015; Ge et al., 2009; Noureddin et al., 2013; Patin et al., 2012; Rauch et al., 2010; Suppiah et al., 2009; Tanaka et al., 2009; Thomas et al., 2009).