FAK knockdown and FAK inhibitor studies support an important role for FAK in promoting invasive tumor growth (Ward et al., 2013; Tancioni et al., 2014), yet the targets downstream of FAK are varied and may be tumor or stroma context-dependent (Sulzmaier et al., 2014; Haemmerle et al., 2016). This evidence concerns the gene PTK2 and neoplasm.