Physical activity is essential in reducing morbidity and mortality associated with diabetes mellitus and maintaining quality of life.4 Regular physical activity reduces high blood sugar in diabetes mellitus patients by improving the sensitivity of skeletal muscles to insulin which may result in the reduction of medication in-take.5,6,7 Furthermore, moderate and vigorous physical activity contributes to weight reduction, improved cardiovascular fitness and over all emotional well-being for patients living with diabetes mellitus.5 The gene discussed is INS; the disease is diabetes mellitus.