ALB and fibrosis: Schnabl et al performed 68Ga-labeled DTPA-conjugated neogalactosyl human serum albumin ([68Ga]DTPA-GSA; Figure 6B), using T90 values to characterize [68Ga]GSA uptake in monitoring hepatic fibrosis and progression of NASH in rats.45 In their PET imaging studies, animals with dominant pattern F0 (a rat with a healthy liver) to F1 (a rat with early or mild fibrosis) demonstrated significantly faster accumulation of [68Ga]GSA (T90: 2.40 ± 0.52 minutes) than those with moderate to advanced dominant pattern fibrosis F2 (moderate fibrosis) and F4 (cirrhotic liver; T90: 3.48 ± 1.01 minutes).