ASGR1 and liver disorder: Asialoglycoprotein receptors (ASGPRs) are well known to colocalize with the mammalian liver, of which 90% exists on sinusoidal faces of hepatocytes and only 10% on lateral faces.35,36 The expression of ASGPR on the hepatocytes of patients with liver disease is reduced and recognized as a diagnostic biomarker for the evaluation of liver function.