Studies have shown that VEGF‐C and VEGF‐D bind to its receptor VEGFR‐2 (KDR) and receptor VEGFR‐3 (Flt‐4), promoting angiogenesis and/or lymphangiogenesis, thus accelerates tumor growth and metastasis (Joukov et al., 1996). Here, FLT4 is linked to neoplasm.