HECTD4 and type 2 diabetes mellitus: An interaction of alcohol with the ADH1C *1/*2 variant (Figure 2, Table S6) was reported by NHS.34 The ADH1C*2‐allele, which is related to a slower rate of ethanol oxidation, attenuated the lower diabetes risk among alcohol drinking US women.34 In contrast, such an interaction was not observed among US men.34 In addition, a T2D gene risk score (GRS) in NHS and HPFS35 and two HECTD4 variants in KoGES36 showed no interaction with alcohol.