Findings (Figure 2, Table S6) indicate that the association of heme iron with T2D incidence is modified by a GRS of nine T2D associated loci33 and genetic variants of HFE (homeostatic iron regulator),38, 40SLC40A1 (iron‐regulated transporter),40 and TMPRSS6 gene (transmembrane serine proteinase).40 In HPFS 33, US men with high heme iron intake and high adherence to a T2D‐GRS had a higher T2D risk compared with other exposure strata. This evidence concerns the gene HFE and type 2 diabetes mellitus.