CDKAL1 and prediabetes syndrome: In EPIC‐InterAct, a stronger T2D risk lowering effect with higher coffee intake has been observed for persons with the risk T‐allele of the TCF7L2 variant rs12255372.24 In KARE,32 only coffee consumers with the rs4402960 T‐allele (IGF2BP2), rs7754840 G‐allele (CDKAL1), and rs5215 CC‐genotype (KCNJ11) had a reduced combined prediabetes and T2D risk compared with nonconsumer.32 Besides these findings, several other genetic variants showed no interaction with coffee, olive oil, or dairy products (Figure 2).