In DPP, the weight loss intervention was associated with a reduced T2D incidence among persons with the diabetogenic variant of ENPP1 rs1044498,72 and a trend for interaction was found for MC4R rs17066829.73 Reported interaction findings from DPS54, 66, 71, 74 indicate that the weight loss intervention resulted in a lower T2D incidence among persons with the PPARγ rs1152003 CC‐genotype,54 the TNFα rs1800629 GG‐genotype,71 the ADRA2B Glu9‐allele,66 and the LIPC rs2070895 A‐allele74 compared with the reference genotypes. The gene discussed is MC4R; the disease is type 2 diabetes mellitus.