INS and type 2 diabetes mellitus: G × PA interaction findings indicate that individuals at high genetic risk for T2D may profit less from the protective effects of PA on T2D risk than individuals at low genetic risk for T2D.49, 55, 57 Nevertheless, for some T2D risk variants, it was shown that affected individuals can also lower their enhanced T2D risk if they are more physically active.48, 54 So far, it remains unclear whether these modifying T2D risk effects are attributable to inferior insulin secretion, insulin sensitivity, and ß‐cell dysfunctions in those individuals.