TNF and type 2 diabetes mellitus: In DPP, the weight loss intervention was associated with a reduced T2D incidence among persons with the diabetogenic variant of ENPP1 rs1044498,72 and a trend for interaction was found for MC4R rs17066829.73 Reported interaction findings from DPS54, 66, 71, 74 indicate that the weight loss intervention resulted in a lower T2D incidence among persons with the PPARγ rs1152003 CC‐genotype,54 the TNFα rs1800629 GG‐genotype,71 the ADRA2B Glu9‐allele,66 and the LIPC rs2070895 A‐allele74 compared with the reference genotypes.