WNT/β‐catenin pathway plays a crucial role in regulation process of cell proliferation, differentiaton, and tumourigenesis, and it has been recognized as a target of ncRNA in cancer proliferation and EMT of carcinogenesis.17 Further molecular biology experiment illustrated that the protein levels of β‐catenin, MMP‐9, and N‐cadherin, which could promote carcinogenesis, were decreased markedly; by contrary, metastatic suppress protein E‐cadherin was increased notably both in miR‐425‐mimic or SNHG7‐siRNA transfected HepG2 and HCC‐LM3 cells. This evidence concerns the gene CDH2 and hepatocellular carcinoma.