Almost all cases present with signs and symptoms related to the pituitary gland which includes endocrine abnormalities of the anterior pituitary gland, headache, visual abnormalities, diabetes insipidus, cranial nerve palsies or apoplexy.1–5–8–12 The hormonal deficiencies may occur in around 30 to 50% of cases and include disorders of growth hormone, gonadotropin and the adreno corticotrophin hormones especially if it involves the hypothalamus. The gene discussed is GH1; the disease is diabetes insipidus.