However, some authors have reported that warfarin does not interfere with LAC detection tests done with dVVRT ratio method.35 Others have described methods to tests LAC in patients on anti-coagulation.36 Also, various studies have tried to stratify the risk of thrombosis (initial or recurrent) and pregnancy loss based on aPL profiles and risk scores like Global APS score or GAPSS.37 GAPSS is based on independent thrombosis and pregnancy loss risk factors and has proven in different cohorts of primary and secondary APS to be associated with higher risks of thrombosis and pregnancy loss.38 This evidence concerns the gene LCT and Venous thrombosis.