To assess the expression of the β3-AR, and whether it is modulated by an hypoxic environment, we cultured three different NB cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C), under normoxia (21% O2) and hypoxia (1% O2) conditions for 24 h. This evidence concerns the gene ADRB3 and neuroblastoma.