ALK and neuroblastoma: Interestingly, NeuroD1 has been also involved in the induction of anaplastic lymphoma kinase (ALK), known to be one of the most important predisposition genes for NB [39] tumorigenesis, thus, hinting that NeuroD1 down-regulation in SR59230A-treated tumors could counteract ALK in sustaining the NB tumorigenesis.