Studies unequivocally showed that people with T2DM were more likely to have lower MM36–43 through several mechanisms, such as decreased glucose utilization by muscle53, increased levels of systemic inflammatory cytokines such as interlukin-6, TNF-alpha, and C-reactive protein54,55 oxidative stress56, and mitochondrial dysfunction57. The gene discussed is TNF; the disease is type 2 diabetes mellitus.