SLC33A1 and Hepatic steatosis: When taken together, the results obtained with AT-1S113R/+ and AT-1 sTg mice indicate that changes in AT-1 activity and acetyl-CoA flux from the cytosol to the ER lumen can cause important changes in the availability of acetyl-CoA within the cytosol, impacting lipid metabolism and propensity to hepatic steatosis.