Many over-expressed genes in tumor-associated T cells were involved in tissue remodeling (e.g., Col1a1, Col4a1, Fn1, Lamc1, Mmp2, Mmp10, Timp3) and cell motility/adhesion (Rhoc, Itga1, Itgav) (Supplementary Fig. 10). This evidence concerns the gene COL1A1 and neoplasm.