While only 20% of the immunized B6 mice were completely protected, with the remaining 80% exhibiting an approximate 2-day delay in the onset of blood stage patency (Fig. 1c), 90% of the immunized IFNAR−/− mice and 100% of immunized IRF3−/− mice were completely protected as they exhibited no signs of blood stage infection (Fig. 1c). The gene discussed is IRF3; the disease is infection.