PPARG and type 2 diabetes mellitus: Notably, the top ‘astrocyte-’ and ‘BD-modifying’ drugs act via PPAR-γ, namely piogliatazone (top ‘astrocyte-modifying’ drug, Table 1a) and betulinic acid (top ‘BD-modifying’ drug, Table 1b), both of which are used in the treatment of type-II diabetes, and in the case of piogliatazone has shown promising results for its anti-depressant activity in clinical trials54,55.