Nevertheless, due to the known role of NCAM in regulating the FGF pathway through its association with FGFR that results in FGFR recycling at the cell surface45,46, sustained signaling36, and cancer progression47, we believe that downregulation of NCAM1 by the antibody interferes with the NCAM/FGFR interplay which may result in reduction of tumor aggressiveness and metastatic properties as was shown in other cancers47. This evidence concerns the gene NCAM1 and cancer.