According to Enrichr database DAZAP2 directly interacts with HGS, NEDD4, UBQLN4, UBB, UBC, MAP3K7, SMURF2, CTNNB1, ATXN1, and RPS27A93, most of these genes have been reported before to be associated with major depression, depression symptomatology, as well as exposure to stress94–101. This evidence concerns the gene SMURF2 and major depressive disorder.