Other studies that investigated DNA methylation signatures of depression in discordant monozygotic twins study design implicated epigenetic changes in VDR26, HOXB7, CACNA1C, STK32C, NR1C3, and MYC genes among others, but not in KLK8 or DAZAP247,108,117,118. Here, CACNA1C is linked to depressive disorder.