HOTAIRM1 and central nervous system cancer: However, hsa-miR-129-5p and hsa-miR-495-3p inhibitors restored the expression of only a subset of hub genes following depletion of HOTAIRM1, indicating that the latter promotes malignancy and regulates the TME in glioma not only by sponging hsa-miR-129-5p and hsa-miR-495-3p but also by enhancing the expression of some hub genes within a non-ceRNA.