Elevated HOTAIRM1 was linked to high risk factors including older age (≥ 50 years), lower KPS, mesenchymal subtype, wild-type IDH, unmethylated MGMT promoter, and 1p/19q non-codeletion, whereas protective factors such as wild-type PTEN and TP53 were associated with glioma samples showing low HOTAIRM1 expression. This evidence concerns the gene TP53 and central nervous system cancer.