As shown in Figure 1B1-B2, Kindlin-3fl/flPF4-Cre mice exhibited significantly compromised DVT when compared to control Kindlin-3fl/fl mice after partial ligation of the IVC for 2 days, showing that kindlin-3 in platelets plays an essential role in promoting DVT. The gene discussed is FERMT3; the disease is deep vein thrombosis.