PPARGC1A and age-related macular degeneration: PGC-1α: EI-12 - Compared to untreated AMD cybrids, significant PGC-1α upregulation was observed in PU-91-treated, P (PU-91)+EI-12 5 μM (216%), P+EI-12 10 μM (263%), P+EI-12 20 μM (115%) groups, and only EI-12 20 μM (82%) groups (Figure 8A, Supplementary Table 4).