Caspase-3: EI-12 - Compared to untreated AMD cybrids, significant Caspase-3 downregulation was observed in PU-91-treated, P+EI-12 5 μM (22%), P+EI-12 10 μM (27%), P+EI-12 20 μM (34%), and only EI-12 20 μM (26%) groups (Figure 8B, Supplementary Table 4). This evidence concerns the gene CASP3 and age-related macular degeneration.