Furthermore, as hypothesized, PU-91-treated AMD cells showed lower Overlap object count (i.e., Caspase-3/7 Green + NucLight Red staining (Yellow))/ Red object count compared to their untreated counterparts i.e., at 48 h – 32% decrease; p=0.03; AMD UN: 1 ± 0.079, n=4; AMD PU-91: 0.68 ± 0.05, n=4 (Figure 5B (c)) and at 72 h – 50.21% decrease; p=0.03; AMD UN: 1 ± 0.082, n=4, AMD PU-91: 0.498 ± 0.084, n=4 (Figure 5B (d)). Here, CASP3 is linked to age-related macular degeneration.