Treatment with PU-91 + EI-12/ EI-78 at different concentrations i.e., EI-12: 5 μΜ, 10 μΜ, and 20 μΜ; EI-78: 2.5 μΜ, 5 μΜ, and 10 μΜ altered the expression of PGC-1α, Caspase-3, IL-18, VEGF, SOD2 genes in AMD RPE cybrid cells (n=3) at the 72 h time point. This evidence concerns the gene CASP3 and age-related macular degeneration.