Treatment of AMD RPE cells with PU-91 decreased expression of Caspase-3 gene by 34% (p=0.016; AMD UN: 1 ± 0.099, n=5; AMD PU-91: 0.66 ± 0.03, n=5) (Figure 4A) and BAX gene by 21% (p=0.0079; AMD UN: 1 ± 0.05, n=5; AMD PU-91: 0.79 ± 0.03, n=5) (Figure 4B), and significantly increased cell viability by 55% (p=0.03; AMD UN: 1 ± 0.11, n=4; AMD PU-91: 1.55 ± 0.086, n=4) (Figure 4C) compared to their untreated counterparts. Here, CASP3 is linked to age-related macular degeneration.