IL-18: EI-12 - Compared to untreated AMD cybrids, significant IL-18 downregulation was observed only in the PU-91-treated group, P+EI-12 5 μM (18.3%), P+EI-12 20 μM (22.4%), and only EI-12 20 μM (22%) groups (Figure 8C, Supplementary Table 4). This evidence concerns the gene IL18 and age-related macular degeneration.