HIF1A and age-related macular degeneration: Furthermore, PU-91-treated AMD cells showed upregulation of SOD2, a mitochondrial antioxidant gene, by 160%, (p=0.0079; AMD UN: 1 ± 0.11, n=5; AMD PU-91: 2.6 ± 0.37, n=5) (Figure 2C), and reduced gene expression of HIF1α (47% increase; p=0.03; AMD UN: 1 ± 0.14, n=4; AMD PU-91: 0.53 ± 0.03, n=4) (Figure 2D).