MCAT and age-related macular degeneration: Treatment with PU-91 drug caused a 104% higher expression of MT-RNR2 gene in AMD RPE cybrid cells (p=0.0079; AMD UN: 1 ± 0.15, n=5; AMD PU-91: 2.04 ± 0.39 n=5) (Figure 2E), suggesting that increased production of Mitochondrial Derived Peptides (MDPs) could be one of the mechanisms by which PU-91 rescues cells.