PPARGC1A and age-related macular degeneration: EI-78 - Compared to untreated AMD cybrids, significant PGC-1α upregulation was observed in PU-91-treated, P+EI-78 2.5 μM (189%), P+EI-78 5 μM (109%), and P+EI-78 10 μM (126%) groups, (Figure 9A, Supplementary Table 5).