NOTCH1 and hepatocellular carcinoma: Taken together, using multiple and complementary approaches in multiple samples including patient HCC tissues and HCC cell lines of low (PLC/PRF5, HepG2 and SMMC7721) and high (SK-HEP-1, HCCLM3 and HCCLM6) metastatic potentials, as well as using the survival analysis, we clearly demonstrated that increased expression of Notch1 correlates with increased metastasis of HCC.