CD274 and neoplasm: In UC, VENTANA SP142 assesses the proportion of tumor area occupied by PD-L1-stained immune cells (IC) (% of ICTumorArea), while VENTANA SP263 utilizes the proportion of ICs with PD-L1 staining as a proportion of the IC area as well as the proportion of tumor cells (TCs) with PD-L1 membrane staining (% of TC or ICICArea) (Fig. 1).