When HCC cells treated with exosomes derived from HCC cells with CLEC3Bhigh or CLEC3Blow, it was found that mRNA and protein expression of Slug was negatively correlative to CLEC3B, and E-cad and ZO-1 had positive correlation to CLEC3B (Fig. 2e-f and Additional file 8: Figure S6D-S6E). The gene discussed is SNAI2; the disease is hepatocellular carcinoma.