CD63 and hepatocellular carcinoma: Moreover, similar with previous reports on the location of CLEC3B [38], we also found that CLEC3B co-localized with some CD63-positive secretory vesicles in CLEC3Bhigh Huh7 cells, and the level changes of CLEC3B could be detected in purified exosomes from CLEC3Bhigh (Exo-3B) or CLEC3Blow (Exo-3B-KD) cells, which indicated that CLEC3B is a component of exosomes derived from HCC cells (Fig. 2c-d and Additional file 7: Figure S5A).