Studies on candidate genes and GWASs identified several genes variation associated with rotator cuff tears, such as DEFB1, FGFR1, FGFR3, ESRRB, FGF10, MMP-1, TNC, FCRL3, SASH1, SAP30BP, rs71404070 located next to cadherin8. This evidence concerns the gene MMP1 and rotator cuff syndrome.