The type of glucose lowering therapy may contribute to the increased risk of hypoglycemia, and some anti-diabetic agents (metformin, alpha-glucosidase inhibitors, thiazolidinediones, GLP-1 receptor agonists, DPP-4 inhibitors) are known to be safer in this respect than others (insulin, sulfonylureas, or glinides) [34, 35]. This evidence concerns the gene INS and Hypoglycemia.